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In a recent report in Nature, Julie Canman and colleagues challenge the widely held view that the symmetrical bipolar spindle is required for cleavage-site formation. In an elegant set of
experiments, they used a small-molecule inhibitor to block the kinesin Eg5, which is essential for establishing a bipolar spindle. As this inhibition activated the spindle checkpoint, they
blocked this checkpoint as well.
What they found was that monopolar half-spindles formed, but that furrow formation and cytokinesis still occurred. The cell-division plane formed on the side of the cell facing the
chromosomes and not at the poles. So, these results showed that two opposing microtubule arrays are not essential for cell division.
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