Cell surface antigenic changes induced in normal adult rat liver cells by carcinogen treatment in vitro


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ABSTRACT Normal rat liver cell lines treated with the chemical carcinogen N-methyl-N-nitrosourea (MNU) elicited antibody production (detected by membrane immunofluorescence test _in vitro_)


when injected into a highly inbred strain of rats from which the liver cells were originally isolated. In contrast, the control cells which were untreated did not evoke humoral antibodies.


Antisera raised against the MNU-treated cells reacted not only with the immunizing cells, but also with 3'-methyl-4-dimethyl aminoazobenzene and 3-methylcholanthrene-treated cells.


However, this antiserum failed to react with cells treated with either aflatoxin or N-acetoxy-2-acetyl-aminofluorene. Embryonic antigens were found to be absent from the normal adult liver


cell line. Preliminary results indicated that none could be detected on carcinogen-treated cells either. Access through your institution Buy or subscribe This is a preview of subscription


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2020 Authors * P T Iype View author publications You can also search for this author inPubMed Google Scholar * R W Baldwin View author publications You can also search for this author


inPubMed Google Scholar * D Glaves View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE


CITE THIS ARTICLE Iype, P., Baldwin, R. & Glaves, D. Cell Surface Antigenic Changes Induced in Normal Adult Rat Liver Cells by Carcinogen Treatment _in vitro_. _Br J Cancer_ 27, 128–133


(1973). https://doi.org/10.1038/bjc.1973.17 Download citation * Issue Date: 01 February 1973 * DOI: https://doi.org/10.1038/bjc.1973.17 SHARE THIS ARTICLE Anyone you share the following link


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