Expression of n-cadherin adhesion molecules associated with early morphogenetic events in chick development


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ABSTRACT Selective adhesive properties of cells are thought to have a key role in animal morphogenesis1, but the molecular bases underlying these properties remain to be determined. Our


studies have demonstrated that cell-type-specific adhesiveness resides in a class of cell-cell adhesion molecules, termed cadherins, which were defined as the molecular components of the


Ca2+-dependent cell adhesion system (CADS)2,3. For example, a cadherin molecule identified in mouse teratocarcinoma cells, termed E-cadherin (this molecule seems to be identical to


uvomorulin4 or cell-CAM 120/80 (ref. 5) and equivalent to chicken L-CAM6), was detected only in epithelial cells of various organs2,3; it did not cross-react with cadherins on other cell


types7,8. We recently described a novel type of cadherin, N-cadherin, which is found in mouse cells and whose tissue distribution is distinct from that of E-cadherin3. In the present study,


we have identified a molecular component of N-cadherin in the chicken and determined its distribution in the tissues of early embryos. The results suggest that expression of this adhesion


molecule is associated with separation and sealing of cell layers in morphogenesis. Access through your institution Buy or subscribe This is a preview of subscription content, access via


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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NON-JUNCTIONAL ROLE OF CADHERIN3 IN CELL MIGRATION AND CONTACT


INHIBITION OF LOCOMOTION VIA DOMAIN-DEPENDENT, OPPOSING REGULATION OF RAC1 Article Open access 15 October 2020 REDUNDANT TYPE II CADHERINS DEFINE NEUROEPITHELIAL CELL STATES FOR


CYTOARCHITECTONIC ROBUSTNESS Article Open access 15 October 2020 STRUCTURAL BASIS FOR REGULATION OF CELSR1 BY A COMPACT MODULE IN ITS EXTRACELLULAR REGION Article Open access 28 April 2025


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Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo-ku,


Kyoto, 606, Japan Kohei Hatta & Masatoshi Takeichi Authors * Kohei Hatta View author publications You can also search for this author inPubMed Google Scholar * Masatoshi Takeichi View


author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hatta, K., Takeichi, M.


Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. _Nature_ 320, 447–449 (1986). https://doi.org/10.1038/320447a0 Download citation


* Received: 28 June 1985 * Accepted: 21 October 1985 * Issue Date: 03 April 1986 * DOI: https://doi.org/10.1038/320447a0 SHARE THIS ARTICLE Anyone you share the following link with will be


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