Repeated inescapable stress produces a neuroleptic-like effect on the conditioned avoidance response


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ABSTRACT This study tests the hypothesis that the dopaminergic system mediates a restitutive response by decreasing its own activity in the face of events like persistent inescapable stress


that threaten to interrupt organized mental activity. It is well established that neuroleptic drugs inhibit the conditioned avoidance response (CAR), but not the escape response, probably


via a reduction in subcortical dopaminergic activity. We trained rats to perform the CAR and then subjected them to acute and chronic stress to determine whether this would result in


inhibition of the CAR. Rats subjected to twice daily tailshock stress for 8 days showed inhibition of the CAR and a reduction in dopamine (DA) utilization in the nucleus accumbens. These


findings are compatible with the hypothesis that an endogenous DA-dependent mechanism exists that mimics neuroleptic effects in the face of repeated stress. In humans this response may serve


as a protection against psychotic decompensation from chronic endogenous or exogenous insult. SIMILAR CONTENT BEING VIEWED BY OTHERS NUCLEUS REUNIENS INACTIVATION REVERSES STRESS-INDUCED


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STRESS-INDUCED DEPRESSIVE-LIKE BEHAVIOR IN MICE Article Open access 18 November 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychiatry, From the Millhauser


Laboratories, New York University School of Medicine, New York Arnold J Friedhoff MD, Kenneth D Carr Ph.D, Suzan Uysal Ph.D & Jack Schweitzer Ph.D Authors * Arnold J Friedhoff MD View


author publications You can also search for this author inPubMed Google Scholar * Kenneth D Carr Ph.D View author publications You can also search for this author inPubMed Google Scholar *


Suzan Uysal Ph.D View author publications You can also search for this author inPubMed Google Scholar * Jack Schweitzer Ph.D View author publications You can also search for this author


inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Friedhoff, A., Carr, K., Uysal, S. _et al._ Repeated Inescapable Stress Produces


a Neuroleptic-like Effect on the Conditioned Avoidance Response. _Neuropsychopharmacol_ 13, 129–138 (1995). https://doi.org/10.1016/0893-133X(95)00047-H Download citation * Received: 03


October 1994 * Revised: 07 November 1994 * Accepted: 15 January 1995 * Published: 01 October 1995 * Issue Date: 01 October 1995 * DOI: https://doi.org/10.1016/0893-133X(95)00047-H SHARE THIS


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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Conditioned avoidance response * Dopamine * Stress * Restitutive systems